Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice
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منابع مشابه
Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/- lipodystrophic mice independent of hepatocyte leptin receptors.
Leptin is essential for energy homeostasis and regulation of food intake. Patients with congenital generalized lipodystrophy (CGL) due to mutations in 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) and the CGL murine model (Agpat2(-/-) mice) both have severe insulin resistance, diabetes mellitus, hepatic steatosis, and low plasma leptin levels. In this study, we show that continuous le...
متن کاملHuman AGPAT isoforms 1 and 2: Biochemical characterization and their inability to rescue hepatic steatosis in Agpat2 lipodystrophic mice
Anil K. Agarwal, Ph.D. Division of Nutrition and Metabolic Diseases Center for Human Nutrition Department of Internal Medicine University of Texas Southwestern Medical Center 5323 Harry Hines Blvd., Dallas, TX 75390, U.S.A. Ph: 214-648-7685 Fax: 214-648-0553 E-mail: [email protected] http://www.jbc.org/cgi/doi/10.1074/jbc.M111.250449 The latest version is at JBC Papers in Press. P...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2016
ISSN: 0022-2275
DOI: 10.1194/jlr.m065896